Our research explores a fundamental problem in cell biology: how a single membrane can generate and maintain distinct domains with specialized structures and functions. We address this question by investigating the biogenesis, dynamics, and organization of the endoplasmic reticulum and nuclear envelope — two functionally distinct domains within a single continuous membrane network. 

We combine cutting edge live-cell imaging approaches with biochemistry, genetic, and -omic analyses in diverse cellular contexts, from C. elegans to distinct cancer cell lineages, connecting molecular tractibility with physiological relevance in vivo.